Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 10.09.21 02:20 | 10.09.21 02:20 | Tampa Bay Buccaneers | Dallas Cowboys | 31:29 | 4 - 7 - 7 |
| 12.09.21 19:00 | 12.09.21 19:00 | Houston Texans | Jacksonville Jaguars | 37:21 | 5 - 7 - 5 |
| 12.09.21 19:00 | 12.09.21 19:00 | Detroit Lions | San Francisco 49ers | 33:41 | 7 - 7 - 4 |
| 12.09.21 19:00 | 12.09.21 19:00 | Cincinnati Bengals | Minnesota Vikings | 27:24OT | 7 - 7 - 4 |
| 12.09.21 19:00 | 12.09.21 19:00 | Carolina Panthers | New York Jets | 19:14 | 4 - 7 - 6 |
| 12.09.21 19:00 | 12.09.21 19:00 | Buffalo Bills | Pittsburgh Steelers | 16:23 | 4 - 7 - 6 |
| 12.09.21 19:00 | 12.09.21 19:00 | Atlanta Falcons | Philadelphia Eagles | 6:32 | 4 - 7 - 5 |
| 12.09.21 19:00 | 12.09.21 19:00 | Washington Football Team | Los Angeles Chargers | 16:20 | 5 - 7 - 4 |
| 12.09.21 19:00 | 12.09.21 19:00 | Tennessee Titans | Arizona Cardinals | 13:38 | 4 - 7 - 6 |
| 12.09.21 19:00 | 12.09.21 19:00 | Indianapolis Colts | Seattle Seahawks | 16:28 | 7 - 7 - 4 |
| 12.09.21 22:25 | 12.09.21 22:25 | New York Giants | Denver Broncos | 13:27 | 5 - 7 - 5 |
| 12.09.21 22:25 | 12.09.21 22:25 | New Orleans Saints | Green Bay Packers | 38:3 | 7 - 7 - 4 |
| 12.09.21 22:25 | 12.09.21 22:25 | New England Patriots | Miami Dolphins | 16:17 | 4 - 7 - 5 |
| 12.09.21 22:25 | 12.09.21 22:25 | Kansas City Chiefs | Cleveland Browns | 33:29 | 4 - 7 - 7 |
| 13.09.21 02:20 | 13.09.21 02:20 | Los Angeles Rams | Chicago Bears | 34:14 | 4 - 7 - 7 |
| 14.09.21 02:15 | 14.09.21 02:15 | Las Vegas Raiders | Baltimore Ravens | 33:27OT | 7 - 7 - 4 |