Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 10.12.21 02:20 | 10.12.21 02:20 | Minnesota Vikings | Pittsburgh Steelers | 36:28 | 4 - 7 - 5 |
| 12.12.21 19:00 | 12.12.21 19:00 | Cleveland Browns | Baltimore Ravens | 24:22 | 6 - 7 - 4 |
| 12.12.21 19:00 | 12.12.21 19:00 | Carolina Panthers | Atlanta Falcons | 21:29 | 4 - 7 - 5 |
| 12.12.21 19:00 | 12.12.21 19:00 | New York Jets | New Orleans Saints | 9:30 | 7 - 7 - 4 |
| 12.12.21 19:00 | 12.12.21 19:00 | Kansas City Chiefs | Las Vegas Raiders | 48:9 | 4 - 7 - 7 |
| 12.12.21 19:00 | 12.12.21 19:00 | Houston Texans | Seattle Seahawks | 13:33 | 7 - 7 - 4 |
| 12.12.21 19:00 | 12.12.21 19:00 | Tennessee Titans | Jacksonville Jaguars | 20:0 | 4 - 7 - 7 |
| 12.12.21 19:00 | 12.12.21 19:00 | Washington Football Team | Dallas Cowboys | 20:27 | 7 - 7 - 4 |
| 12.12.21 22:05 | 12.12.21 22:05 | Denver Broncos | Detroit Lions | 38:10 | 4 - 7 - 7 |
| 12.12.21 22:05 | 12.12.21 22:05 | Los Angeles Chargers | New York Giants | 37:21 | 4 - 7 - 7 |
| 12.12.21 22:25 | 12.12.21 22:25 | Tampa Bay Buccaneers | Buffalo Bills | 33:27OT | 4 - 7 - 7 |
| 12.12.21 22:25 | 12.12.21 22:25 | Cincinnati Bengals | San Francisco 49ers | 23:26OT | 5 - 7 - 5 |
| 13.12.21 02:20 | 13.12.21 02:20 | Green Bay Packers | Chicago Bears | 45:30 | 4 - 7 - 7 |
| 14.12.21 02:15 | 14.12.21 02:15 | Arizona Cardinals | Los Angeles Rams | 23:30 | 4 - 7 - 6 |