Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 17.12.21 02:20 | 17.12.21 02:20 | Los Angeles Chargers | Kansas City Chiefs | 28:34OT | 7 - 7 - 4 |
| 19.12.21 02:15 | 19.12.21 02:15 | Indianapolis Colts | New England Patriots | 27:17 | 6 - 7 - 4 |
| 19.12.21 19:00 | 19.12.21 19:00 | Buffalo Bills | Carolina Panthers | 31:14 | 4 - 7 - 7 |
| 19.12.21 19:00 | 19.12.21 19:00 | Miami Dolphins | New York Jets | 31:24 | 4 - 7 - 7 |
| 19.12.21 19:00 | 19.12.21 19:00 | Detroit Lions | Arizona Cardinals | 30:12 | 7 - 7 - 4 |
| 19.12.21 19:00 | 19.12.21 19:00 | Pittsburgh Steelers | Tennessee Titans | 19:13 | 6 - 7 - 4 |
| 19.12.21 19:00 | 19.12.21 19:00 | Jacksonville Jaguars | Houston Texans | 16:30 | 5 - 7 - 5 |
| 19.12.21 19:00 | 19.12.21 19:00 | New York Giants | Dallas Cowboys | 6:21 | 7 - 7 - 4 |
| 19.12.21 22:05 | 19.12.21 22:05 | San Francisco 49ers | Atlanta Falcons | 31:13 | 4 - 7 - 7 |
| 19.12.21 22:05 | 19.12.21 22:05 | Denver Broncos | Cincinnati Bengals | 10:15 | 5 - 7 - 4 |
| 19.12.21 22:25 | 19.12.21 22:25 | Baltimore Ravens | Green Bay Packers | 30:31 | 7 - 7 - 4 |
| 20.12.21 02:20 | 20.12.21 02:20 | Tampa Bay Buccaneers | New Orleans Saints | 0:9 | 4 - 7 - 7 |
| 20.12.21 23:00 | 20.12.21 23:00 | Cleveland Browns | Las Vegas Raiders | 14:16 | 4 - 7 - 5 |
| 21.12.21 02:15 | 21.12.21 02:15 | Chicago Bears | Minnesota Vikings | 9:17 | 7 - 7 - 4 |
| 22.12.21 01:00 | 22.12.21 01:00 | Philadelphia Eagles | Washington Football Team | 27:17 | 5 - 7 - 5 |
| 22.12.21 01:00 | 22.12.21 01:00 | Los Angeles Rams | Seattle Seahawks | 20:10 | 4 - 7 - 7 |