Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 01.10.21 02:20 | 01.10.21 02:20 | Cincinnati Bengals | Jacksonville Jaguars | 24:21 | 4 - 7 - 7 |
| 03.10.21 19:00 | 03.10.21 19:00 | Atlanta Falcons | Washington Football Team | 30:34 | 5 - 7 - 5 |
| 03.10.21 19:00 | 03.10.21 19:00 | Miami Dolphins | Indianapolis Colts | 17:27 | 5 - 7 - 5 |
| 03.10.21 19:00 | 03.10.21 19:00 | Buffalo Bills | Houston Texans | 40:0 | 4 - 7 - 7 |
| 03.10.21 19:00 | 03.10.21 19:00 | Chicago Bears | Detroit Lions | 24:14 | 5 - 7 - 5 |
| 03.10.21 19:00 | 03.10.21 19:00 | Minnesota Vikings | Cleveland Browns | 7:14 | 6 - 7 - 4 |
| 03.10.21 19:00 | 03.10.21 19:00 | New Orleans Saints | New York Giants | 21:27OT | 4 - 7 - 7 |
| 03.10.21 19:00 | 03.10.21 19:00 | Dallas Cowboys | Carolina Panthers | 36:28 | 4 - 7 - 5 |
| 03.10.21 19:00 | 03.10.21 19:00 | Philadelphia Eagles | Kansas City Chiefs | 30:42 | 7 - 7 - 4 |
| 03.10.21 19:00 | 03.10.21 19:00 | New York Jets | Tennessee Titans | 27:24OT | 7 - 7 - 4 |
| 03.10.21 22:05 | 03.10.21 22:05 | Los Angeles Rams | Arizona Cardinals | 20:37 | 4 - 7 - 7 |
| 03.10.21 22:05 | 03.10.21 22:05 | San Francisco 49ers | Seattle Seahawks | 21:28 | 5 - 7 - 5 |
| 03.10.21 22:25 | 03.10.21 22:25 | Denver Broncos | Baltimore Ravens | 7:23 | 5 - 7 - 4 |
| 03.10.21 22:25 | 03.10.21 22:25 | Green Bay Packers | Pittsburgh Steelers | 27:17 | 4 - 7 - 7 |
| 04.10.21 02:20 | 04.10.21 02:20 | New England Patriots | Tampa Bay Buccaneers | 17:19 | 7 - 7 - 4 |
| 05.10.21 02:15 | 05.10.21 02:15 | Los Angeles Chargers | Las Vegas Raiders | 28:14 | 5 - 7 - 5 |