Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 15.10.21 02:20 | 15.10.21 02:20 | Philadelphia Eagles | Tampa Bay Buccaneers | 22:28 | 7 - 7 - 4 |
| 17.10.21 15:30 | 17.10.21 15:30 | Jacksonville Jaguars | Miami Dolphins | 23:20 | 5 - 7 - 4 |
| 17.10.21 19:00 | 17.10.21 19:00 | Carolina Panthers | Minnesota Vikings | 28:34OT | 5 - 7 - 5 |
| 17.10.21 19:00 | 17.10.21 19:00 | Baltimore Ravens | Los Angeles Chargers | 34:6 | 5 - 7 - 5 |
| 17.10.21 19:00 | 17.10.21 19:00 | Chicago Bears | Green Bay Packers | 14:24 | 7 - 7 - 4 |
| 17.10.21 19:00 | 17.10.21 19:00 | Detroit Lions | Cincinnati Bengals | 11:34 | 7 - 7 - 4 |
| 17.10.21 19:00 | 17.10.21 19:00 | Indianapolis Colts | Houston Texans | 31:3 | 4 - 7 - 7 |
| 17.10.21 19:00 | 17.10.21 19:00 | New York Giants | Los Angeles Rams | 11:38 | 7 - 7 - 4 |
| 17.10.21 19:00 | 17.10.21 19:00 | Washington Football Team | Kansas City Chiefs | 13:31 | 7 - 7 - 4 |
| 17.10.21 22:05 | 17.10.21 22:05 | Cleveland Browns | Arizona Cardinals | 14:37 | 5 - 7 - 4 |
| 17.10.21 22:25 | 17.10.21 22:25 | New England Patriots | Dallas Cowboys | 29:35OT | 6 - 7 - 4 |
| 17.10.21 22:25 | 17.10.21 22:25 | Denver Broncos | Las Vegas Raiders | 24:34 | 5 - 7 - 5 |
| 18.10.21 02:20 | 18.10.21 02:20 | Pittsburgh Steelers | Seattle Seahawks | 23:20OT | 4 - 7 - 5 |
| 19.10.21 02:15 | 19.10.21 02:15 | Tennessee Titans | Buffalo Bills | 34:31 | 7 - 7 - 4 |