Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 22.10.21 02:20 | 22.10.21 02:20 | Cleveland Browns | Denver Broncos | 17:14 | 4 - 7 - 6 |
| 24.10.21 19:00 | 24.10.21 19:00 | Baltimore Ravens | Cincinnati Bengals | 17:41 | 4 - 7 - 7 |
| 24.10.21 19:00 | 24.10.21 19:00 | Miami Dolphins | Atlanta Falcons | 28:30 | 5 - 7 - 4 |
| 24.10.21 19:00 | 24.10.21 19:00 | Green Bay Packers | Washington Football Team | 24:10 | 4 - 7 - 7 |
| 24.10.21 19:00 | 24.10.21 19:00 | Tennessee Titans | Kansas City Chiefs | 27:3 | 5 - 7 - 4 |
| 24.10.21 19:00 | 24.10.21 19:00 | New England Patriots | New York Jets | 54:13 | 4 - 7 - 7 |
| 24.10.21 19:00 | 24.10.21 19:00 | New York Giants | Carolina Panthers | 25:3 | 7 - 7 - 4 |
| 24.10.21 22:05 | 24.10.21 22:05 | Las Vegas Raiders | Philadelphia Eagles | 33:22 | 4 - 7 - 7 |
| 24.10.21 22:05 | 24.10.21 22:05 | Los Angeles Rams | Detroit Lions | 28:19 | 4 - 7 - 7 |
| 24.10.21 22:25 | 24.10.21 22:25 | Tampa Bay Buccaneers | Chicago Bears | 38:3 | 4 - 7 - 7 |
| 24.10.21 22:25 | 24.10.21 22:25 | Arizona Cardinals | Houston Texans | 31:5 | 4 - 7 - 7 |
| 25.10.21 02:20 | 25.10.21 02:20 | San Francisco 49ers | Indianapolis Colts | 18:30 | 4 - 7 - 5 |
| 26.10.21 02:15 | 26.10.21 02:15 | Seattle Seahawks | New Orleans Saints | 10:13 | 5 - 7 - 4 |