Spielplan
| Termin | Tipptermin | Heim | Gast | Ergebnis | Punkteregel |
|---|---|---|---|---|---|
| 05.11.21 01:20 | 05.11.21 01:20 | Indianapolis Colts | New York Jets | 45:30 | 4 - 7 - 7 |
| 07.11.21 19:00 | 07.11.21 19:00 | New York Giants | Las Vegas Raiders | 23:16 | 7 - 7 - 4 |
| 07.11.21 19:00 | 07.11.21 19:00 | Miami Dolphins | Houston Texans | 17:9 | 4 - 7 - 6 |
| 07.11.21 19:00 | 07.11.21 19:00 | Jacksonville Jaguars | Buffalo Bills | 9:6 | 7 - 7 - 4 |
| 07.11.21 19:00 | 07.11.21 19:00 | Cincinnati Bengals | Cleveland Browns | 16:41 | 4 - 7 - 5 |
| 07.11.21 19:00 | 07.11.21 19:00 | Baltimore Ravens | Minnesota Vikings | 34:31OT | 4 - 7 - 7 |
| 07.11.21 19:00 | 07.11.21 19:00 | Carolina Panthers | New England Patriots | 6:24 | 7 - 7 - 4 |
| 07.11.21 19:00 | 07.11.21 19:00 | Dallas Cowboys | Denver Broncos | 16:30 | 4 - 7 - 7 |
| 07.11.21 19:00 | 07.11.21 19:00 | New Orleans Saints | Atlanta Falcons | 25:27 | 4 - 7 - 7 |
| 07.11.21 22:05 | 07.11.21 22:05 | Philadelphia Eagles | Los Angeles Chargers | 24:27 | 7 - 7 - 4 |
| 07.11.21 22:25 | 07.11.21 22:25 | San Francisco 49ers | Arizona Cardinals | 17:31 | 6 - 7 - 4 |
| 07.11.21 22:25 | 07.11.21 22:25 | Kansas City Chiefs | Green Bay Packers | 13:7 | 4 - 7 - 5 |
| 08.11.21 02:20 | 08.11.21 02:20 | Los Angeles Rams | Tennessee Titans | 16:28 | 4 - 7 - 7 |
| 09.11.21 02:15 | 09.11.21 02:15 | Pittsburgh Steelers | Chicago Bears | 29:27 | 4 - 7 - 7 |